Pafinur FuMarate
Rupatadine fumarate
CAS: 182349-12-8
Molecular Formula: C26H26ClN3.C4H4O4
Pafinur FuMarate - Names and Identifiers
| Name | Rupatadine fumarate |
| Synonyms | Rupax FuMarate Rupafin FuMarate Pafinur FuMarate Rinialer FuMarate Rupatadine Fumarate RUPATADINE FUMARATE Rupatadine fumarate Alergoliber FuMarate 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5h-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate |
| CAS | 182349-12-8 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C26H26ClN3.C4H4O4/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25;5-3(6)1-2-4(7)8/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
Pafinur FuMarate - Physico-chemical Properties
| Molecular Formula | C26H26ClN3.C4H4O4 |
| Molar Mass | 532.03 |
| Melting Point | 196-198°C |
| Solubility | Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | White to Pale Brown |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ?0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α. |
| In vivo study | Rupatadine blocks histamine- and PAF-induced effects in vivo, such as hypotension in rats (ID50 = 1.4 and 0.44 mg/kg i.v., respectively) and bronchoconstriction in guinea pigs (ID50 = 113 and 9.6 μg/kg i.v.). Moreover, it potently inhibits PAF-induced mortality in mice (ID50 = 0.31 and 3.0 mg/kg i.v. and p.o., respectively) and endotoxin-induced mortality in mice and rats (ID50 = 1.6 and 0.66 mg/kg i.v.). Rupatadine's duration of action is long, as assessed by the histamine- and PAF-induced increase in vascular permeability test in dogs (42 and 34% inhibition at 26 h after 1 mg/kg p.o.). Rupatadine at a dose of 100 mg/kg p.o. neither modifies spontaneous motor activity nor prolongs barbiturate-sleeping time in mice, which indicates a lack of sedative effects. |
Pafinur FuMarate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.88 ml | 9.398 ml | 18.796 ml |
| 5 mM | 0.376 ml | 1.88 ml | 3.759 ml |
| 10 mM | 0.188 ml | 0.94 ml | 1.88 ml |
| 5 mM | 0.038 ml | 0.188 ml | 0.376 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: Rupatadine Fumarate Visit Supplier Webpage Request for quotationCAS: 182349-12-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Rupatadine Fumarate Visit Supplier Webpage Request for quotationCAS: 182349-12-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History